Glutathione and Coenzyme Q10 Show No Additive Neuroprotective Effect at the Neuromuscular Junction of Crayfish

Abstract

This study examined the effects of antioxidants Coenzyme Q10 and Glutathione at the neuromuscular junction of crayfish. We hypothesized that a solution containing both Coenzyme Q10 and Glutathione would show higher EJPs then each of the antioxidants independently. Microelectrodes were inserted into the superficial extensor muscles of a crayfish tail to record the excitatory junction potential (EJP) of crayfish exposed to three different combinations of antioxidants in response to a neurodegenerative substance (hydrogen peroxide). We found that there was no significant additive effect when Coenzyme Q10 and Glutathione are applied together on preventing neuromuscular degeneration