Blocking of muscarinic receptors does not affect post tetanic response in frog neuromuscular junction
Abstract
Post-tetanic potentiation (PTP) is an often-studied form of synaptic plasticity that is associated with motor learning. Although the exact physiological mechanism is as yet unknown, there is some evidence that muscarinic receptors may play a role in this process, as muscarinic antagonists have been shown to prevent the induction of long-term potentiation by tetanic stimulation. However, after observing the effects of the general muscarinic inhibitor atropine on the end-plate potentials (EPPs) of the frog sartorius muscle, we report preliminary data suggesting that muscarinic receptors do not play a significant role in the induction of PTP. Observations of the amplitude of the EPPs suggest that muscarinic receptors do play a role in the modulation of neurotransmitter (NT) release in the neuromuscular junction (NMJ), as evidenced by the decrease in EPP amplitude in the presence of the muscarinic antagonist atropine.
Published
2005-05-17
How to Cite
MARION, Brian; MCLEAN, Kimberly; NAGEL, Ana.
Blocking of muscarinic receptors does not affect post tetanic response in frog neuromuscular junction.
Pioneering Neuroscience, [S.l.], v. 6, p. 5-8, may 2005.
Available at: <https://ojs.grinnell.edu/index.php/pnsj/article/view/117>. Date accessed: 12 oct. 2021.
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