Long term depression decreased in crayfish chronically exposed to Fluoxetine

Abstract

Research is limited on the effects of Fluoxetine on living organisms. Due to that fact, we studied the effects of Fluoxetine, a specific SSRI (Selective Serotonin Reuptake Inhibitors), on crayfish superficial extensor muscles. In this study, excitatory junction potential (EJP) amplitudes were measured using intracellular recording on two different groups of crayfish one with acute exposure to fluoxetine and another with chronic exposure. We found that although acute fluoxetine exposure did not affect long-term depression (LTD), chronic exposure to the drug reduced LTD.