TY  - JOUR
AU  - Cao, Angela
AU  - Su, Zheng
PY  - 2007/12/19
TI  -  Inhibition of the reverse mode of the Na + /Ca 2+  exchanger does not affect EPSP amplitudes in the crayfish neuromuscular junction following periods of brief, high-frequency stimulation
JF  - Pioneering Neuroscience; Vol 8 (2007)
KW  - 
N2  - Calcium plays a major role in synaptic transmission in which it triggers the release of neurotransmitters into the synaptic cleft. The cell maintains low Ca 2+  intracellular concentrations by various mechanisms including the Na + / Ca 2+  exchanger. This exchanger pumps out 1 Ca 2+  ion in exchange for 3 Na+ ions. In some instances however the Na + / Ca 2+  is capable of functioning in the reverse mode, in which the exchanger pumps out 3 Na +  ions in exchange for 1 Ca 2+  ion. We investigated the influence of exchanger’s reverse mode in synaptic facilitation. We inhibited the reverse mode of the Na + / Ca 2+  exchanger with the chemical KB-R7943. We induced synaptic facilitation in the presyanptic cell with a five second period of high-frequency stimulation of 20 Hz. However, we found no statistical difference in EPSP amplitude when the reverse mode of the Na + / Ca 2+  was inhibited compared to EPSP amplitudes without KB-R7943.
UR  - https://ojs.grinnell.edu/index.php/pnsj/article/view/99