TY  - JOUR
AU  - Saliares, Ellen
AU  - Peterson, Sam
AU  - Moon, Hoh
PY  - 2007/12/19
TI  -  Reduction of endoplasmic reticulum internal calcium stores via BHQ decreases EJP amplitude
JF  - Pioneering Neuroscience; Vol 8 (2007)
KW  - 
N2  - Synaptic transmission requires Ca 2+  to initiate the release of neurotransmitters. While the mechanism that allows this is not known, we do know that Ca2+ allows the vesicles containing these neurotransmitters to fuse with the neuron’s membrane. Ca 2+  is released from internal Ca 2+  stores like the endoplasmic reticulum when a signal is sent to the nerve terminal. This Ca 2+  re-enters the endoplasmic reticulum internal stores through SERCA pumps. These pumps can be inhibited by the chemical butylhydroquinone (BHQ). This causes a depletion of Ca 2+  within the internal stores and reduces the removal of free Ca 2+  from the cytosol. The inhibition of these internal stores has both an immediate and long-term effect on the amplitudes and duration of the EJPs. In the present work we found that amplitude initially fell after the inhibition, but eventually rose until it reached the values from before the BHQ was added. Duration grew steadily longer after the BHQ was added. These results show that the role of endoplasmic reticulum as internal Ca 2+  stores is important in maintaining both functional amplitude and duration.
UR  - https://ojs.grinnell.edu/index.php/pnsj/article/view/98