TY  - JOUR
AU  - Rast, Rosemary
AU  - Ryan, Grace
AU  - Sittig, Katherine
PY  - 2010/12/21
TI  -  2-APB Negates the Enhancement of EPSP Amplitudes Induced by 5-HT in the  Procambaris clarkii  Neuromuscular Junction.
JF  - Pioneering Neuroscience; Vol 11 (2010)
KW  - 
N2  - 5-HT is known to increase the amplitude of excitatory postsynaptic potentials (EPSPs) in the crayfish neuromuscular junction, but it is not known how 5-HT does this. It is possible that 5-HT acts through IP 3 -induced intracellular Ca 2+  release. To test this, we bathed a crayfish neuromuscular junction in a solution of 5-HT plus the IP 3  inhibitor 2-APB and measured EPSP amplitudes. We compared these with EPSP measurements taken in a solution with 5-HT alone. We found that the application of the IP 3  inhibitor counteracts the amplitude-increasing effect of 5-HT. This supports our hypothesis that 5-HT works through IP 3 -induced Ca 2+  increase to increase the amplitudes of EPSPs in the crayfish neuromuscular junction.
UR  - https://ojs.grinnell.edu/index.php/pnsj/article/view/54