%A Rast, Rosemary
%A Ryan, Grace
%A Sittig, Katherine
%D 2010
%T  2-APB Negates the Enhancement of EPSP Amplitudes Induced by 5-HT in the  Procambaris clarkii  Neuromuscular Junction.
%K 
%X 5-HT is known to increase the amplitude of excitatory postsynaptic potentials (EPSPs) in the crayfish neuromuscular junction, but it is not known how 5-HT does this. It is possible that 5-HT acts through IP 3 -induced intracellular Ca 2+  release. To test this, we bathed a crayfish neuromuscular junction in a solution of 5-HT plus the IP 3  inhibitor 2-APB and measured EPSP amplitudes. We compared these with EPSP measurements taken in a solution with 5-HT alone. We found that the application of the IP 3  inhibitor counteracts the amplitude-increasing effect of 5-HT. This supports our hypothesis that 5-HT works through IP 3 -induced Ca 2+  increase to increase the amplitudes of EPSPs in the crayfish neuromuscular junction.
%U https://ojs.grinnell.edu/index.php/pnsj/article/view/54
%J Pioneering Neuroscience
%0 Journal Article
%P 1-4%V 11
%8 2010-12-21