%A Schmidt, Jessica N
%A Young, Kendra M
%D 2013
%T  Nitric oxide synthase inhibitor reduces muscarinic-mediated depression of EPP values at the frog neuromuscular junction
%K 
%X We investigated the role of nitric oxide (NO) in the modulation of muscarinic receptor-mediated depression of acetylcholine (ACh) release at the frog neuromuscular junction (NMJ). We activated muscarinic receptors at the frog NMJ using Oxotremorine-M (Oxo-M), a muscarinic agonist, in the presence and absence of N-?-Nitro-Larginine- methyl-ester (L-NAME), an NO synthase inhibitor. We found that Oxo-M depressed end plate potential (EPPs) values in the absence of L-NAME. However, we found that pretreatment with L-NAME eliminated this Oxo-M-induced depression at the frog NMJ.
%U https://ojs.grinnell.edu/index.php/pnsj/article/view/165
%J Pioneering Neuroscience
%0 Journal Article
%P 11-16%V 3
%8 2013-01-11