%A Barreto, Tyler
%A Meinig, Michelle
%A Seo, Mae
%D 2005
%T  P/Q-type Calcium Channels Contribute to the Release of Neurotransmitters when N-type Calcium Channels are Inhibited in the Crayfish Neuromuscular Junction
%K 
%X Neurotransmitter release is caused by an influx of calcium through voltage gated calcium channels in the presynaptic terminal. To learn more about voltage gated calcium channels, we applied Omega-Conotoxin GVIA solution to the crayfish neuromuscular junction. With this toxin, we were able to block one type of voltage-dependant calcium channel, the N-type calcium channel. We predicted that the excitatory post synaptic potential (EPSP) amplitude would decrease, but not disappear completely, because of the compensation of calcium ion influx by the P/Q-type calcium channels. We found that the EPSP amplitude decreased significantly, recovered slightly, and then gradually decreased again following the application of Omega-Conotoxin GVIA solution.
%U https://ojs.grinnell.edu/index.php/pnsj/article/view/124
%J Pioneering Neuroscience
%0 Journal Article
%P 35-38%V 6
%8 2005-05-17