TY - JOUR AU - Pathania, Manav AU - Wichmann, Grete AU - Niedergeses, Lisa PY - 2005/05/17 TI - M 2 receptor mediates a decrease in ACh release at the frog neuromuscular junction JF - Pioneering Neuroscience; Vol 6 (2005) KW - N2 - Muscarinic receptors have been implicated in modulating ACh release at vertebrate neuromuscular junctions (NMJ). We characterized the roles of M 2 and M 3 receptors at the frog NMJ by pharmacologically isolating each receptor and measuring ACh release in terms of EPP amplitude. We observed an M 2 mediated inhibition of ACh release and no apparent involvement of M 3 receptors. We conclude that muscarinic responses in the frog are unlike those observed in the lizard or the rat. UR - https://ojs.grinnell.edu/index.php/pnsj/article/view/121